Olive oil protects against chromosomal aberrations induced by doxorubicin in wistar rat bone marrow cells
| Autor: | Antunes Lusânia Maria Greggi, Takahashi Catarina Satie |
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| Jazyk: | angličtina |
| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | Genetics and Molecular Biology, Vol 22, Iss 2, Pp 223-227 (1999) |
| Druh dokumentu: | article |
| ISSN: | 1415-4757 1678-4685 |
| Popis: | There is considerable interest in identifying dietary compounds which have the capacity to protect against chromosomal aberrations induced by antitumor agents. Fatty acids and their constituents are able to act as free radical scavengers. Doxorubicin (DXR) is an important chemotherapeutic agent, that also induces chromosome aberrations. Rat bone marrow cells treated simultaneously with olive oil (10 ml/kg body weight) and DXR (90 mg/kg body weight) developed significantly fewer chromosomal aberrations and abnormal metaphases than those treated with DXR alone. |
| Databáze: | Directory of Open Access Journals |
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