Platelet Glycoprotein Ⅵ: A Novel Target for Antithrombotic Therapy in Cardiovascular Disease

Autor: Menglu Liu, Xueyan Zhao, Hanjia Gao
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Cardiology Discovery, Vol 4, Iss 4, Pp 309-318 (2024)
Druh dokumentu: article
ISSN: 2096-952X
00000000
DOI: 10.1097/CD9.0000000000000137
Popis: Abstract. Platelets play an important role in thrombosis caused by acute coronary syndrome and stroke. As the main platelet collagen receptor, platelet glycoprotein Ⅵ (GPⅥ) is an important modulator in the activation and aggregation of platelets at vascular injury sites. Recently, GPⅥ has been identified as a potent antithrombotic target. The structure, properties, functions, and downstream signaling of GPⅥ are reviewed; its relationship with bleeding, thrombosis, and other diseases are discussed; and potential of GPⅥ as a future antiplatelet therapeutic target is summarized in this article.
Databáze: Directory of Open Access Journals
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