Platelet Glycoprotein Ⅵ: A Novel Target for Antithrombotic Therapy in Cardiovascular Disease
Autor: | Menglu Liu, Xueyan Zhao, Hanjia Gao |
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Jazyk: | angličtina |
Rok vydání: | 2024 |
Předmět: | |
Zdroj: | Cardiology Discovery, Vol 4, Iss 4, Pp 309-318 (2024) |
Druh dokumentu: | article |
ISSN: | 2096-952X 00000000 |
DOI: | 10.1097/CD9.0000000000000137 |
Popis: | Abstract. Platelets play an important role in thrombosis caused by acute coronary syndrome and stroke. As the main platelet collagen receptor, platelet glycoprotein Ⅵ (GPⅥ) is an important modulator in the activation and aggregation of platelets at vascular injury sites. Recently, GPⅥ has been identified as a potent antithrombotic target. The structure, properties, functions, and downstream signaling of GPⅥ are reviewed; its relationship with bleeding, thrombosis, and other diseases are discussed; and potential of GPⅥ as a future antiplatelet therapeutic target is summarized in this article. |
Databáze: | Directory of Open Access Journals |
Externí odkaz: |
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