The relationship between serum vitamin D concentrations and development of diabetic retinopathy in type 2 diabetes mellitus
| Autor: | V.I. Pankiv, T.Yu. Yuzvenko, N.V. Pashkovska, I.V. Pankiv |
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| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Mìžnarodnij Endokrinologìčnij Žurnal, Vol 18, Iss 8, Pp 432-435 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2224-0721 2307-1427 |
| DOI: | 10.22141/2224-0721.18.8.2022.1221 |
| Popis: | Background. The literature does not provide enough information about the role of vitamin D in the genesis of diabetic retinopathy. The active metabolite of vitamin D, calcitriol, is a potent retinal neovascularization inhibitor in an experimental model of ischemic retinopathy. There is very few evidence on the possible relationship between the content of vitamin D and the incidence of diabetic retinopathy in type 2 diabetes mellitus (DM) patients in the European population, including Ukraine. The purpose of the study is to establish the association between vitamin D status and the incidence of diabetic retinopathy in patients with type 2 DM. Material and methods. In the case-control observational study, two groups of patients with type 2 DM were examined: 55 with diabetic retinopathy (cases) and 35 without retinopathy (controls). All of them had normal kidney function (glomerular filtration rate > 60 ml/min, without microalbuminuria) in the absence of cardiovascular complications. Patients did not receive calcium and/or vitamin D preparations. Results. The study confirms the relationship between 25(OH)D content and the presence of diabetic retinopathy in patients with type 2 DM. Patients with retinopathy had a significantly lower concentration of 25(OH)D — 14.6 ± 2.9 ng/ml versus 23.9 ± 3.1 ng/ml in patients without retinopathy, p |
| Databáze: | Directory of Open Access Journals |
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