| Autor: |
Jie Li, Xiancang Ma, Bin Zhang, Wanting Feng, Shiqi Yuan, Tong Yu, Chengfeng Chen, Yuqing Yang, Mingqia Wang, Yantianyu Yang |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
General Psychiatry, Vol 37, Iss 4 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2517-729X |
| DOI: |
10.1136/gpsych-2023-101412 |
| Popis: |
Background Observational studies highlight the association between gut microbiota (GM) composition and depression; however, evidence for the causal relationship between GM and specific depressive symptoms remains lacking.Aims We aimed to evaluate the causal relationship between GM and specific depressive symptoms as well as the mediating role of body mass index (BMI).Methods We performed a two-sample Mendelian randomisation (MR) analysis using genetic variants associated with GM and specific depressive symptoms from genome-wide association studies. The mediating role of BMI was subsequently explored using mediation analysis via two-step MR.Results MR evidence suggested the Bifidobacterium genus (β=–0.03; 95% CI –0.05 to –0.02; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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