Enantioselective synthesis of chiral amides by carbene insertion into amide N–H bond

Autor: Xuan-Ge Zhang, Zhi-Chun Yang, Jia-Bin Pan, Xiao-Hua Liu, Qi-Lin Zhou
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Druh dokumentu: article
ISSN: 2041-1723
91248477
DOI: 10.1038/s41467-024-48266-5
Popis: Abstract Chiral amides are important structure in many natural products and pharmaceuticals, yet their efficient synthesis from simple amide feedstock remains challenge due to its weak Lewis basicity. Herein, we describe our study of the enantioselective synthesis of chiral amides by N-alkylation of primary amides taking advantage of an achiral rhodium and chiral squaramide co-catalyzed carbene N–H insertion reaction. This method features mild condition, rapid reaction rate (in all cases 1 min) and a wide substrate scope with high yield and excellent enantioselectivity. Further product transformations show the synthetic potential of this reaction. Mechanistic studies reveal that the non-covalent interactions between the catalyst and reaction intermediate play a critical role in enantiocontrol.
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