| Autor: |
Motoh Iwasa, Yoshinao Kobayashi, Rumi Mifuji-Moroka, Nagisa Hara, Hirohide Miyachi, Ryosuke Sugimoto, Hideaki Tanaka, Naoki Fujita, Esteban C Gabazza, Yoshiyuki Takei |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 8, Iss 7, p e70309 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0070309 |
| Popis: |
Long-term supplementation with branched-chain amino acids (BCAA) is associated with prolonged survival and decreased frequency of development of hepatocellular carcinoma (HCC) in patients with liver cirrhosis. However, the pharmaceutical mechanism underlying this association is still unclear. We investigated whether continuous BCAA supplementation increases survival rate of rats exposed to a fibrogenic agent and influences the iron accumulation, oxidative stress, fibrosis, and gluconeogenesis in the liver. Further, the effects of BCAA on gluconeogenesis in cultured cells were also investigated. A significant improvement in cumulative survival was observed in BCAA-supplemented rats with advanced cirrhosis compared to untreated rats with cirrhosis (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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