Hepatocentric approach to achieving compensation of diabetes mellitus in people with non-alcoholic steatohepatitis
| Autor: | N.M. Protas, I.O. Kostitska, M.V. Bielinskyi |
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| Jazyk: | English<br />Ukrainian |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Mìžnarodnij Endokrinologìčnij Žurnal, Vol 20, Iss 5, Pp 375-382 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2224-0721 2307-1427 |
| DOI: | 10.22141/2224-0721.20.5.2024.1423 |
| Popis: | Background. Non-alcoholic steatohepatitis (NASH) in individuals with type 2 diabetes mellitus (T2DM) is considered a comorbid condition with an unfavorable prognosis and a significant economic burden on the global healthcare system. Despite patient-centered treatment goals and the coordinated efforts of a multidisciplinary team of physicians, a significant proportion of patients fail to achieve glycemic control, indicating the complex and multifactorial pathogenesis of T2DM. Achieving glycemic targets with a hepatocentric approach should be considered an alternative way to improve the treatment algorithm for patients with T2DM and NASH. The purpose of the study was to evaluate the hepatoprotective effect of dapagliflozin on achieving glycemic control in individuals with T2DM and NASH. Materials and methods. Sixty patients with T2DM and NASH were examined and divided into two groups based on antidiabetic therapy: group I (n = 30) received basic medical therapy (BMT) which included metformin (2000 mg/day), alpha-lipoic acid (600 mg/day), and rosuvastatin (10 mg/day) in combination with insulin therapy; group II (n = 30) received BMT in combination with dapagliflozin at a daily dose of 10 mg. All patients underwent comprehensive laboratory tests, including calculations of non-invasive screening biomarkers (HEPAmet fibrosis score) and liver fibrosis severity (Fibrosis-4 index, FIB-4), as well as clinical and instrumental diagnostics using liver shear wave elastography (METAVIR, kPa). The study period lasted 12 weeks. Results. After 3 months of treatment, group I showed a tendency toward normalization of glycemic control parameters, while the level of glycated hemoglobin significantly decreased (∆ –22.92 %, p |
| Databáze: | Directory of Open Access Journals |
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