Accurate immune repertoire sequencing reveals malaria infection driven antibody lineage diversification in young children

Autor: Ben S. Wendel, Chenfeng He, Mingjuan Qu, Di Wu, Stefany M. Hernandez, Ke-Yue Ma, Eugene W. Liu, Jun Xiao, Peter D. Crompton, Susan K. Pierce, Pengyu Ren, Keke Chen, Ning Jiang
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-017-00645-x
Popis: Somatic hypermutation of antibodies can occur in infants but are difficult to track. Here the authors present a new method called MIDCIRS for deep quantitative repertoire sequencing with few cells, and show infants as young as 3 months can expand antibody lineage complexity in response to malaria infection.
Databáze: Directory of Open Access Journals