The importance of transmembrane domain interactions in the viral control of apoptosis

Autor:	Gerard Duart, Ismael Mingarro, Luis Martinez-Gil
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	viral bcl2 apoptosis poxvirus herpesvirus transmembrane Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular & Cellular Oncology, Vol 8, Iss 3 (2021)
Druh dokumentu:	article
ISSN:	2372-3556 23723556
DOI:	10.1080/23723556.2021.1911290
Popis:	Viral control of apoptosis occurs through the expression of viral encoded anti-apoptotic B-cell lymphoma 2 (BCL2) analogs. These proteins are thought to restrain apoptosis by interacting with cellular BCL2 family members. We identified that protein-protein interactions between cellular and viral BCL2 transmembrane domains are crucial for the viral protein’s function.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ee38483f627c4e60a415cb617edcb7ed Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF