Blastocyst culture depends on quality of embryos on day 3, not quantity

Autor: Natarajamani Sasikala, Ayyappan Rajapriya, Subramaniam Mahalakshmi, Dakshina Moorthy Janani, Bharghav Archana, P.J. Parameaswari
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Middle East Fertility Society Journal, Vol 20, Iss 4, Pp 224-230 (2015)
Druh dokumentu: article
ISSN: 1110-5690
DOI: 10.1016/j.mefs.2015.01.004
Popis: Study objective: Our aim was to find whether the number really matters and if good blastocysts can be developed even with less numbers on day 3 provided quality is good. Design: A retrospective analysis of all fresh ICSI cycles with a maximum of 6 embryos on day 3, excluding Donor Oocyte, donor embryo and frozen embryo cycles was done. Setting: A Tertiary Infertility Centre in the metro city Chennai, India. Materials and methods: A total number of 84 ICSI cycles with 320 embryos were categorized into six groups based on the day 3 embryo numbers in each cohort. Main outcome measure: ANOVA was used to compare the mean blastocyst formation between these groups and was statistically significant (P = 0.000). Diagnostic Efficacy for these groups was tested using F1 Score and Mathew’s Correlation Coefficient. Conclusion: Incidence of blast formation rate for the Case group with embryos (1–3) was observed to be 91.5% and 83.2% for the Control group with embryos (>3) and was significant with an overall pregnancy rate 40.5%. Blastocyst culture is possible even with less numbers on day 3 if the quality of embryos is good.
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