Heterogeneidad biológica y clínica de la leucemia linfoide aguda pediátrica de fenotipo T Biological and clinical heterogeneity of the phenotype T childhood acute lymphoid leukemia

Autor: Vianed Marsán Suárez, Yanelkys Cos Padrón, Lillian Teresa Fuentes de Armas, Bertha Beatriz Socarrás Ferrer, Miriam Sánchez Segura, Aramís Núñez Quintana, Eva Svarch Guerchicoff, Rosa Lam Díaz, Lázaro O del Valle Pére, Consuelo Macías Abraham
Jazyk: Spanish; Castilian
Rok vydání: 2005
Předmět:
Zdroj: Revista Cubana de Hematología, Inmunología y Hemoterapia, Vol 21, Iss 1, p 0 (2005)
Druh dokumentu: article
ISSN: 0864-0289
1561-2996
Popis: Se estudiaron las características biológicas y clínicas de 31 niños con leucemia linfoide aguda de fenotipo T (LLA-T) en un período de 14 años. El inmunofenotipaje celular se realizó mediante los métodos inmunocitoquímicos (UMICIQ) y de fosfatasa alcalina anti-fosfatasa alcalina (APAAP). Se observó una mayor incidencia (38,5 %) en el grupo de edad entre 2-5 años. Los niños varones blancos fueron los más afectados. El 61,3 % de los pacientes mostró leucocitos The biological and clinical characteristics of 31 children with phenotype T acute lymphoid leukemia (T-ALL) were studied in a period of 14 years. The cellular immunophenotyping was performed by the immunocytochemical (UMICIQ) and alkaline phosphatase anti-alkaline phosphatase (APAAP) methods. It was observed a higher incidence (38.5 %) in the age group 2-5. The white male children were the most affected. 61.3 % of the patients showed leukocytes < 20x109/L at the onset of the disease. The mean figure of hemoglobin was 8.8x109/L. 71 % presented lymphadenopathies and splenomegalia. Mediastinal mass, hepatomegalia and hemorrhages were found in 32.2 %, 83.9 % and 16.1 %, respectively. 25.8 % had infiltration of the central nervous system. The immunological classification revealed a predominance of the late T-ALL variety (45.2 %) over the early (29 %) and the cortical (25.8 %). 2 (6,4 %) Mi+ T-ALL were diagnosed. These results proved that the T-ALL of the child is a clinical and biologically heterogeneous disease
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