| Autor: |
Allison Sang, Thomas Danhorn, Jacob N. Peterson, Andrew L. Rankin, Brian P. O’Connor, Sonia M. Leach, Raul M. Torres, Roberta Pelanda |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-018-06293-z |
| Popis: |
Conventional B cells express clonally specific antigen receptors, but a small subset of B cells from patients and mice with systematic lupus erythematosus simultaneously expresses two distinct antigen receptors. Here the authors show that these dual-specificity B cells have higher levels of MHC-II, depend on IL-21 for expansion, and mount stronger memory response. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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