Higher daytime systolic BP, prepregnancy BMI and an elevated sFlt-1/PlGF ratio predict the development of hypertension in normotensive pregnant women

Autor: Almudena Lara-Barea, Begoña Sánchez-Lechuga, Manuel Aguilar-Diosdado, Cristina López-Tinoco
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 1477-7827
DOI: 10.1186/s12958-022-01050-w
Popis: Abstract Background The risk of hypertensive disorders of pregnancy (HDP) varies in women with gestational diabetes mellitus (GDM), depending on the degree of insulin resistance and is also influenced by obesity. The aim of this study was to evaluate clinical features, blood pressure (BP) profiles and inflammatory markers, to identify patients with an elevated risk of developing HDP. Methods A total of 146 normotensive pregnant women were studied. We analysed the relationships of BP profiles detected by ambulatory blood pressure monitoring (ABPM) with serum biomarkers and angiogenic factors and their association with the development of HDP. Results Fourteen (9.6%) women developed HDP, of which 11 had GDM and 8 had obesity. Women with HDP had higher values of 24-h and daytime systolic/diastolic BP (113/69 vs. 104/64; 115/72 vs. 106/66 mmHg, respectively; p
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