| Autor: |
Samaneh Davoudi, Ramak Roohipourmoallai, Cynthia M. Guerin, Siva S.R. Iyer |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
American Journal of Ophthalmology Case Reports, Vol 24, Iss , Pp 101216- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2451-9936 |
| DOI: |
10.1016/j.ajoc.2021.101216 |
| Popis: |
Purpose: We describe a 61-year-old female patient with a retinal pigment epithelial detachment (PED) of the left eye in the setting of neovascular aged-macular degeneration (nAMD) with unanticipated responses to aflibercept and bevacizumab. Observations: A reduction of PED size from 423 μm to 309 μm and vision improvement (20/150- to 20/40) were observed after five consecutive monthly injections of bevacizumab. A switch to aflibercept for the following two consecutive months showed an unanticipated incremental decline in vision (20/80- at month 1, 20/150- at month 2), increased PED size (749 μm), and the development of subretinal fluid (SRF). After a switch back to bevacizumab, the subretinal fluid resolved. After nine consecutive monthly injections of bevacizumab, final vision in the left eye was 20/25, and final PED height was 84 μm. Conclusions: Different anti-VEGFs may induce varied and unpredictable responses among the most recalcitrant cases of nAMD. Unpredictably, PED size in our patient worsened with aflibercept treatment. Importance: Treatment for nAMD with large PEDs has poor level 1 evidence for guidance, and customized treatment should be considered. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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