Durable Complete Remission of a Brainstem Glioma Treated with a Combination of Bevacizumab and Cetuximab
| Autor: | Joan Manel Gasent Blesa, Sara Blasco Mollá, María Fonfría Esparcia, JoséMiguel Sempere Ortells, Miguel Peris Godoy, Adrian Munilla Das, Balbino Mancheño Magan, Mariano Provencio Pulla, Jose Luis Sanchez, Juan Bautista Laforga Canales, Vicente Alberola Candel |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Case Reports in Oncology, Vol 5, Iss 3, Pp 676-681 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1662-6575 00034185 |
| DOI: | 10.1159/000341852 |
| Popis: | Treatment of a relapsed glioma is a clinical challenge nowadays. New active treatments are required to treat these difficult diseases. Here we present a durable complete remission of a relapsed glioblastoma that has achieved a complete radiologic response with the combination of cetuximab and bevacizumab, in a third-line setting, that has offered a progression-free survival of 20 months. We consider here both potential mechanisms for the explanation of this result. First, the potential target of the cancer stem cells (CSCs) with these two antibodies, and second, the potential recruitment of the immune system to directly pursue the CSCs. |
| Databáze: | Directory of Open Access Journals |
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