| Autor: |
Xuanji Wang, MD, Patrick Sweigert, MD, MS, Emanuel Eguia, MD, MS, M. Alyssa Varsnik, MD, Christen R. Renz, MD, Weston A. Terrasse, MD, Madeline Gauthier, BA, Gerard Aranha, MD, Lawrence M. Knab, MD, Gerard Abood, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Surgery Open Science, Vol 3, Iss , Pp 34-38 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2589-8450 |
| DOI: |
10.1016/j.sopen.2020.08.001 |
| Popis: |
Introduction: Angiotensin system inhibitors are associated with improved prognosis in patients with gastrointestinal and hepatobiliary cancers. Data suggest that renin–angiotensin system signaling stimulates the tumor's immune microenvironment to impact overall survival. The goal of this study is to investigate the role of angiotensin system inhibitor use on the overall survival and disease-free survival of esophageal cancer patients. Methods: Retrospective review of esophagectomy patients with esophageal adenocarcinoma and squamous cell cancer at a single institution tertiary care center from 2007 to 2018 was performed. Outcomes include overall survival and disease-free survival. Patient characteristics were compared with t test and χ2 test. Survival was analyzed with Kaplan–Meier and Cox proportional-hazards regression. Results: One hundred seventy-one patients were identified and 123 underwent esophagectomy for cancer. No significant differences in patient demographics were found between angiotensin system inhibitor users and non–angiotensin system inhibitor users except for the rates of hypertension (40% vs 94%, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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