Mendelian randomization shows causal effects of birth weight and childhood body mass index on the risk of frailty

Autor:	Junhao Cui, Shuqin Fu, Lin Zhu, Peng Li, Chunlan Song
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	birth weight childhood body mass index frailty Mendelian randomization Public aspects of medicine RA1-1270
Zdroj:	Frontiers in Public Health, Vol 12 (2024)
Druh dokumentu:	article
ISSN:	2296-2565 82465886
DOI:	10.3389/fpubh.2024.1270698
Popis:	BackgroundThe association between birth weight and childhood body mass index (BMI) and frailty has been extensively studied, but it is currently unclear whether this relationship is causal.MethodsWe utilized a two-sample Mendelian randomization (MR) methodology to investigate the causal effects of birth weight and childhood BMI on the risk of frailty. Instrumental variables (p 0.05).ConclusionThis MR study provides evidence supporting a causal relationship between lower birth weight, higher childhood BMI, and an increased risk of frailty.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/3810df0afe824658868859614d704d12 Zobrazit plný text záznamu View record in DOAJ