| Autor: |
Rajiv Saran, Yukari Yamada, Tatsuyoshi Ikenoue, Shingo Fukuma, Jennifer Bragg-Gresham, Edward Norton, Daichi Kohmoto |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
BMJ Open, Vol 10, Iss 9 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2044-6055 |
| DOI: |
10.1136/bmjopen-2020-037247 |
| Popis: |
Background Obesity is a growing public health problem worldwide. We evaluated the mediators and association between changes in obesity metrics and renal outcomes in the general population.Methods Using the Japanese nationwide health check-based cohort from April 2011 to March 2019, we selected individuals aged 40–74 years, with a baseline estimated glomerular filtration rate (eGFR) ≥45 mL/min/1.73 m2, whose body mass index (BMI) change was assessed. The primary outcome was combined 30% decline in eGFR, eGFR 4%) mediated by three risk factors (blood pressure, haemoglobin A1c and total cholesterol), was 13.3%.Conclusion In the middle-aged Japanese population, both, increase and decrease in BMI were associated with subsequent eGFR decline. Changes in risk factors mediated a small proportion of the association between BMI increase and eGFR decline. Our findings support the clinical significance of monitoring BMI as a renal risk factor. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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