Vertebral Collapse Prevented Following Teriparatide Treatment in Postmenopausal Kümmell's Disease Patients with Severe Osteoporosis

Autor: Peng‐guo Gou, Zhi‐hui Zhao, Jia‐ming Zhou, Lin‐hui Ren, Xiao‐yun Wang, Yu‐feng Mu, Yun‐guo Wang, Feng Chang, Yuan Xue
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Orthopaedic Surgery, Vol 13, Iss 2, Pp 506-516 (2021)
Druh dokumentu: article
ISSN: 1757-7861
1757-7853
DOI: 10.1111/os.12959
Popis: Objective To compare the preventive effects of teriparatide and alendronate on the progression of vertebral body collapse in postmenopausal single‐level Kümmell's disease (KD). Methods From March 2013 to December 2020, the medical records for 53 postmenopausal single‐level KD patients who received conservative treatment with teriparatide (25 patients, teriparatide group) or alendronate (28 patients, alendronate group) were retrospectively reviewed. Midsagittal computed tomography (CT) images were analyzed by ImageJ to assess the intravertebral bone formation (mineralized bone) by calculating the ratio of area of intravertebral mineralized bone (AIMB) to the area of fractured vertebral body (AFVB). The changes in radiological parameters of the fractured vertebral body including kyphosis angle (KA), anterior and posterior border heights (ABH and PBH) and spinal canal diameter (SCD), bone turnover biomarkers (BTMs), and bone mineral density (BMD) were analyzed to evaluate the therapeutic effect. Results At month 12, the ratio of AIMB to AFVB was significantly greater in teriparatide group (54.28% ± 15.30%) than in alendronate group (35.57% ± 17.61%) (P
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