Autor: |
Fanfan Zhang, Yangyang Luo, Qipeng Wei, Ligen Xiong, Quan Xie, Jia Tan, Chengcheng Wu, Na Li, Zhaofeng Kang |
Jazyk: |
angličtina |
Rok vydání: |
2024 |
Předmět: |
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Zdroj: |
Poultry Science, Vol 103, Iss 2, Pp 103264- (2024) |
Druh dokumentu: |
article |
ISSN: |
0032-5791 |
DOI: |
10.1016/j.psj.2023.103264 |
Popis: |
ABSTRACT: In recent years, the infection rate of avian encephalomyelitis virus (AEV) infection in chickens has risen significantly, seriously endangering the development of the chicken industry. In order to study the current epidemiological status of AEV in China as well as the genetic and evolutionary patterns of the virus, we conducted a survey and genomic analysis of chicken AEV. The results showed that 46.26% (136/294) of the tissue samples tested (n = 294) were positive for AEV, with the highest positivity rate of 62.24% (61/98) among tissue samples from chickens aged 13 to 18 wk. The complete genomes of 2 representative AEV strains were determined, and the VP1 evolutionary tree results revealed that the 2 representative strains belonged to a novel AEV strain. Multiple alignment analysis showed that the ORF1 genes of the 2 representative strains differed by 82.3 to 99.9% at the amino acid level compared with the reference AEV strain, and the mutations at the key amino acid loci of VP2 and VP3 were the same as those in the chick embryo-adapted strain. The analysis makes up for the molecular epidemiological data and genetic variation of the 2 representative strains. The analysis makes up for the molecular epidemiological data and genetic variation of AEV and provides a basis for further understanding the spread of AEV in China. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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