| Autor: |
Yongjun Wang, Yilong Wang, Xingquan Zhao, Jing Jing, Hao Li, Xia Meng, Yuesong Pan, S Claiborne Johnston, Huimin Chen, Lixia Zong, Yuyuan Xu, Hongyi Yan |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Stroke and Vascular Neurology, Vol 5, Iss 2 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2059-8696 |
| DOI: |
10.1136/svn-2019-000305 |
| Popis: |
Background The effect of cerebral small vessel disease (CSVD) and intracranial arterial stenosis (ICAS) on stroke outcomes remains unclear.Methods Data of 1045 patients with minor stroke or transient ischaemic attack (TIA) were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial. We assessed the associations of burdens of CSVD and ICAS with new strokes and bleeding events using multivariate Cox regression models and those with modified Rankin Scale (mRS) scores using ordinal logistic regression models.Results Among the 1045 patients, CSVD was present in 830 cases (79.4%) and ICAS in 460 (44.0%). Patients with >1 ICAS segment showed the highest risk of new strokes (HR 2.03, 95% CI 1.15 to 3.56, p=0.01). No association between CSVD and the occurrence of new strokes was found. The presence of severe CSVD (common OR (cOR) 2.01, 95% CI 1.40 to 2.89, p1 ICAS segment (cOR 2.15, 95% CI 1.57 to 2.93, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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