snoRNAs and Its Potential Role in Hepatocellular Carcinoma

Autor: SONG Xinxin, WANG Xu, NI Juan
Jazyk: čínština
Rok vydání: 2024
Předmět:
Zdroj: Zhongliu Fangzhi Yanjiu, Vol 51, Iss 4, Pp 284-289 (2024)
Druh dokumentu: article
ISSN: 1000-8578
DOI: 10.3971/j.issn.1000-8578.2024.23.1062
Popis: Small nucleolar RNAs (snoRNAs) are non-coding RNAs in the nucleolus and are mainly responsible for the 2'-O-methylation and pseudouridine modification of rRNA. snoRNAs regulate various biological processes, such as tRNA modification, spliceosome snRNA modification, maintenance of the telomere structure, and alternative splicing of mRNA. Aberrant expression of snoRNA is related to cancer progression, and it may become a new target for cancer treatment. snoRNAs are stable and easy to detect in body fluids, so they can be used as a biomarker for clinical diagnosis and prognostic. This article reviews the biogenesis, classification, structure, and function of snoRNAs and introduces their potential role in the occurrence and development of hepatocellular carcinoma.
Databáze: Directory of Open Access Journals
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