| Autor: |
Ju Young Lee, Sang Hoon Park, Yujin Kim, Young Uk Cho, Jaejin Park, Jung-Hoon Hong, Kyubeen Kim, Jongwoon Shin, Jeong Eun Ju, In Sik Min, Mingyu Sang, Hyogeun Shin, Ui-Jin Jeong, Yuyan Gao, Bowen Li, Aizhan Zhumbayeva, Kyung Yeun Kim, Eun-Bin Hong, Min-Ho Nam, Hojeong Jeon, Youngmee Jung, Huanyu Cheng, Il-Joo Cho, Ki Jun Yu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
npj Flexible Electronics, Vol 6, Iss 1, Pp 1-14 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2397-4621 |
| DOI: |
10.1038/s41528-022-00219-y |
| Popis: |
Abstract Challenges in the understanding of three-dimensional (3D) brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to the difficulties of constructing mechanical design and spatial limitations of the implanted sites. Here, we present a foldable and flexible 3D neural prosthetic that facilitates the 3D mapping of complex neural circuits with high spatiotemporal dynamics from the intracortical to cortical region. This device is the tool to map the 3D neural transmission through sophisticatedly designed four flexible penetrating shanks and surface electrode arrays in one integrated system. We demonstrate the potential possibilities of identifying correlations of neural activities from the intracortical area to cortical regions through continuous monitoring of electrophysiological signals. We also exploited the structural properties of the device to record synchronized signals of single spikes evoked by unidirectional total whisker stimulation. This platform offers opportunities to clarify unpredictable 3D neural pathways and provides a next-generation neural interface. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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