The Effects of Carbon Tetrachloride Administration on Liver and Renal Function
| Autor: | Ruqiah Ganda Putri Panjaitan, Ekowati Handharyani, Chairul Chairul, Masriani Masriani, Zulfa Zakiah, Wasmen Manalu |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Makara Journal of Health Research, Vol 11, Iss 1, Pp 11-16 (2010) |
| Druh dokumentu: | article |
| ISSN: | 2356-3664 2356-3656 |
| DOI: | 10.7454/msk.v11i1.217 |
| Popis: | Carbon tetrachloride (CCl4) that induces liver damage is widely used in hepatoprotector experiments. Carbon tetrachloride at a single dose 0,1; 1,0; and 10 ml/kg body weight was administrated intraperitoneally in male rats to investigate liver and renal damage. Liver damage was monitored by increased alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total bilirubin, and serum total protein. Increased serum creatinine is an indicator of renal problem. Futhermore, liver and renal tissues were subjected to histopathological studies. Compared with control, injection of 0,1 and 1,0 ml CCl4/kg body weight increased ALT and decreased AST, and at dose 10 ml/kg body weight both ALT and AST decreased to a greater extent (p0.05). Carbon tetrachloride at dose 0,1 and 1,0 ml/kg body weight increased creatinine. However, injection of 10 ml CCl4/kg body weight decreased creatinine (p |
| Databáze: | Directory of Open Access Journals |
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