Rheological and Low Field NMR Characterisation of Cystic Fibrosis Patient’s Sputum
| Autor: | G. Staltari, A. Biasin, L. Grassi, F. Gerin, M. Maschio, M. Confalonieri, G. Grassi, M. Grassi, M. Abrami |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Chemical and Biochemical Engineering Quarterly, Vol 36, Iss 4, Pp 239-253 (2023) |
| Druh dokumentu: | article |
| ISSN: | 0352-9568 1846-5153 |
| DOI: | 10.15255/CABEQ.2022.2119 |
| Popis: | The shear modulus G of the sputum obtained by expectoration from cystic fibrosis patients is fundamental to determine the mesh size of the polymeric network pervading the sputum, a parameter related to lung functionality. The Akaike criterion revealed that in 55.2 % of the examined samples, the best approach (among those considered) to determine G relied on the mechanical spectrum fitting by the generalised Maxwell model with relaxation times scaled by a factor 10. Thus, this approach was adopted to evaluate the mesh size distribution combining G knowledge with the determination of the average magnetic relaxation time (T2m) of sputum. As G and T2m determination can be negatively affected by sputum contamination by saliva, whose presence increases T2m and depresses G, we developed a proper “decontamination” procedure to obtain more reliable T2m and G estimations (necessary in 21 % of the samples). This procedure allowed to strengthen the T2m correlation with lung functionality evaluated by FEV1 (normalised air volume emitted in the first second during a spirometry test). |
| Databáze: | Directory of Open Access Journals |
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