Early Allograft Dysfunction After Liver Transplantation With Donation After Circulatory Death and Brain Death Grafts: Does the Donor Type Matter?
| Autor: | Laura Ioana Mazilescu, MD, Sreelakshmi Kotha, MD, Anand Ghanekar, MD, PhD, Leslie Lilly, MD, MSc, Trevor W. Reichman, MD, PhD, Zita Galvin, MD, Mark S. Cattral, MD, MSc, Mamatha Bhat, MD, Ian D. McGilvray, MD, PhD, Gonzalo Sapisochin, MD, Blayne Sayed, MD, PhD, Markus Selzner, MD, Nazia Selzner, MD, PhD |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Transplantation Direct, Vol 7, Iss 8, p e727 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2373-8731 00000000 |
| DOI: | 10.1097/TXD.0000000000001182 |
| Popis: | Background. Early allograft dysfunction (EAD) after liver transplantation has been associated with long-term reduced graft and patient survival. Methods. In this single-center cohort study, we aimed to compare incidence, risk factors, and outcomes in liver transplant recipients who developed EAD. Patients who received donation after circulatory death (DCD) or donation after brain death (DBD) grafts between January 2007 and December 2017 were included. EAD was defined as bilirubin of ≥10 mg/dL (171 μmol/L) or an international normalized ratio of ≥1.6 on postoperative day 7 or transaminases >2000 U\L in the first-week posttransplantation as previously described. Results. In our cohort of 1068 patients, incidence of EAD was 44%. EAD occurred more frequently in the DCD versus DBD group (71% versus 41%, P |
| Databáze: | Directory of Open Access Journals |
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