Altered expression of the DISC1 gene in peripheral blood of patients with schizophrenia

Autor: Xiaoqian Fu, Guofu Zhang, Yansong Liu, Ling Zhang, Fuquan Zhang, Conghua Zhou
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: BMC Medical Genetics, Vol 21, Iss 1, Pp 1-6 (2020)
Druh dokumentu: article
ISSN: 1471-2350
DOI: 10.1186/s12881-020-01132-9
Popis: Abstract Background Schizophrenia is a severe, heritable, and refractory psychiatric disorder. Several studies have shown that the disrupted in schizophrenia 1 (DISC1) gene is closely associated with schizophrenia by its role in neuronal morphology, synaptic function, brain development, and dopamine homeostasis etc. This study intended to investigate the expression levels of DISC1 gene in schizophrenia patients compared with healthy controls, and the expression variation of DISC1 gene before and after antipsychotic treatment in schizophrenia patients. Methods In this study, we compared DISC1 expression levels in blood of 48 healthy controls, and 32 schizophrenia patients before and after 12 weeks of antipsychotic treatment using real-time quantitative PCR (RT-qPCR) analysis. Results The expression levels of DISC1 gene in peripheral blood mononuclear cells of schizophrenia patients before antipsychotic treatment were higher than those in healthy controls (P
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