| Autor: |
Myriam L. Agudelo-Quintero, Ivan Luzardo-Ocampo, Jorge A. Lopera-Rodríguez, Maria E. Maldonado-Celis, Sandra S. Arango-Varela |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Biology and Life Sciences Forum, Vol 18, Iss 1, p 17 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2673-9976 |
| DOI: |
10.3390/Foods2022-12984 |
| Popis: |
The Andean berry is a South American fruit displaying anti-cancer effects. This research aimed to assess the antiproliferative effects of the juice (ABJ) on two human colon cells (SW480/SW620) through viability, proliferation, and Ki67 protein quantification. All treatments (0–30% v/v) reduced viability (50-SW480: 28.19% v/v ABJ; IC50-SW620: 19.43% v/v ABJ). All ABJ-treated cells showed a reduced ki67 amount compared to untreated cells. The highest binding affinity (−9.4 kcal/mol) was shown between cyanidin-3-glucoside and caspase 8 in silico. ABJ exerts antiproliferative/inhibitory effects on SW480/SW620 cells, attributable to polyphenol-apoptotic target interactions. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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