The use of splenectomy to manage platelet transfusion refractoriness due to anti-human leukocyte antibodies in allogeneic stem cell transplantation

Autor:	Margherita Mauro, Francesco Camoglio, Pierluigi Piccoli, Massimiliano De Bortoli, Rita Balter, Anna Pegoraro, Simone Cesaro
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	anti-HLA splenectomy alloimmunized patients transfusion refractoriness allogeneic stem cell transplantation Medicine Pediatrics RJ1-570
Zdroj:	Pediatric Reports, Vol 8, Iss 1 (2016)
Druh dokumentu:	article
ISSN:	2036-749X 2036-7503
DOI:	10.4081/pr.2016.6159
Popis:	In patients undergoing hematopoietic stem cell transplantation (HSCT), refractoriness to platelet transfusion has been associated with graft failure, delayed engraftment, early mortality and decreased overall survival. Therapeutic strategies include plasma exchange, immunoglobulins, rituximab, and splenectomy. We describe here three patients with refractoriness to platelet transfusion due to anti-human leukocyte antibodies who were splenectomized before HSCT (two cases) and after HSCT (one case) due to the lack of efficacy of other therapies. Splenectomy was uneventful. All three patients achieved a full donor engraftment. We suggest that splenectomy is feasible and effective in HSCT patients to reduce the risk of graft failure or delayed engraftment.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ec37a6677abc477a9a6827b996ad8716 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF