| Autor: |
Razieh Kabirifar, Zohreh-al-sadat Ghoreshi, Alireza Rezaifar, Fariba Binesh, Kourosh Bamdad, Ali Moradi |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 40, Iss , Pp 341-348 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2017.11.020 |
| Popis: |
We examined the effects of curcumin, quercetin, and atorvastatin on the hepatic fibrosis through measurement of the protein levels of phospho-AMP-activated protein kinase (p-AMPK) and phospho-acetyl-CoA carboxylase (p-ACC) and gene expression of lipogenic genes in bile duct ligation (BDL)-induced fibrotic rats. We divided male Wistar rats into 8 groups (n = 8 for each), four of which were sham and the remaining four received BDL operations. Each rat in the sham or BDL groups was administered quercetin (30 mg/kg/day), curcumin (100 mg/kg) or atorvastatin (15 mg/kg) for 4 weeks. We found that curcumin, quercetin, and atorvastatin treatment led to up-regulation of p-AMPK and carnitine palmitoyl transferase (CPT1a). However, they suppressed the BDL-mediated increase in sterol regulatory element-binding protein-1c (SREBP-1c), ACC1, fatty acid synthase (FAS) and beta hydroxy beta methylglutaryl-CoA reductase (HMGCR) gene expression (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Full Text from ScienceDirect