Signal transducers and activators of transcription 6 (Stat6) variants in childhood and adult asthma

Autor: Michiko Suzuki, Hirokazu Arakawa, Yasuko Kobayashi, Kazushi Tamura, Hiroyuki Mochizuki, Kenichi Tokuyama, Mayumi Tamari, X.-Q. Mao, Taro Shirakawa, Kenji Izuhara, Akihiro Morikawa
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Zdroj: Allergology International, Vol 53, Iss 3, Pp 241-244 (2004)
Druh dokumentu: article
ISSN: 1323-8930
1440-1592
DOI: 10.1111/j.1440-1592.2004.00340.x
Popis: Background: Signal transducers and activators of transcription 6 (Stat6) is a key transcription factor involved in interleukin (IL)-4 and IL-1 3-mediated biological responses. Recently, we reported the association between the dinucleotide (GT) repeat polymorphism in the first exon of Stat6 and allergic subjects in a Japanese population. The aim of the present study was to evaluate whether this GT repeat polymorphism is associated with bronchial asthma, including childhood asthma and atopic and non-atopic adult asthma. Methods: Stat6 gene polymorphisms were genotyped by polymerase chain reaction (PCR) fragment length polymorphism analysis. Results: In the first exon of Stat6, polymorphic PCR products were classified into six alleles (12–17 GT repeats). A significant difference was found in the genotypic frequency of the GT repeat polymorphism between controls and child asthmatics (P = 0.015), but not atopic or non-atopic adult asthma. The frequency of the 15 repeat allele (wild type) was lower in child asthmatics than in controls (P = 0.0047; odds ratio (OR) 1.6, 95% confidence interval (CI) 1.16-2.23), whereas shorter repeat alleles (12, 13 and 14 GT repeat) were higher in child asthmatics than in controls (P = 0.0064; OR (95%CI) 1.66 (1.15-2.39)). Conclusion: Genetic variations in the Stat6 gene may be associated with a predisposition for childhood asthma.
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