Analysis of Stochastic Time Response of Microfluidic Biosensors in the Case of Competitive Adsorption of Two Analytes

Autor: Ivana Jokić, Zoran Djurić, Katarina Radulović, Miloš Frantlović
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Proceedings, Vol 2, Iss 13, p 991 (2018)
Druh dokumentu: article
ISSN: 2504-3900
DOI: 10.3390/proceedings2130991
Popis: A model of stochastic time response of adsorption-based microfluidic biosensors is presented, that considers the competitive adsorption-desorption process coupled with mass transfer of two analytes. By using the model we analyze the expected value of the adsorbed particles number of each analyte, which determine the sensor response kinetics. The comparison with the case when only one analyte exists is used for investigation of the influence of competitive adsorption on the sensor response. The response kinetics analyzed by using the stochastic model is compared with the kinetics predicted by the deterministic response model. The results are useful for optimization of micro/nanosensors intended for detection of substances in ultra-low concentrations in complex samples.
Databáze: Directory of Open Access Journals