Outbreak of mumps in a student population with high vaccination coverage in China: time for two-dose vaccination
| Autor: | Wei Qin, Yao Wang, Tao Yang, Xiao-Kang Xu, Xiang-Mei Meng, Chang-Jun Zhao, Shao-Yi Li, Shao-Yu Xie, Kai-Chun Li, Hong Su |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Human Vaccines & Immunotherapeutics, Vol 15, Iss 9, Pp 2106-2111 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2164-5515 2164-554X 21645515 |
| DOI: | 10.1080/21645515.2019.1581526 |
| Popis: | In 2016, an outbreak of mumps occurred in a primary school in China with a student population having high vaccination coverage. An unmatched case-control study was performed to identify risk factors contributing to this outbreak, and a retrospective cohort study was conducted to evaluate the effectiveness of mumps-containing vaccine (MuCV). A total of 97 cases were identified during the outbreak, and the overall attack rate was 8.2%. Among students with confirmed vaccination status, 90% had received at least one dose of MuCV. Cases were more likely than non-cases to report taking the school bus during the epidemic period (adjusted OR = 2.3, 95% CI: 1.4–3.7). Vaccine effectiveness (VE) was higher for two-dose MuCV (76%, 95% CI:49–89%) than for one-dose MuCV (59%, 95% CI: 36–74%. The protection afforded by both one-dose and two-dose MuCV waned over time, from 82% among students vaccinated within 5 years to 41% among those vaccinated more than 10 years previously for one-dose VE, and from 90% to 25% over the same time period for two-dose VE. We found that outbreaks of mumps can occur in schools despite high coverage of one-dose MuCV vaccination. Although the VE of both two-dose and one-dose MuCV wanes over time, the overall VE for two-dose MuCV was superior than that of one-dose MuCV. Therefore, a two-dose MuCV schedule through routine services is likely needed in order to control mumps epidemics in China. |
| Databáze: | Directory of Open Access Journals |
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