Exercise transiently increases the density of incipient blood clots in antiplatelet-treated lacunar stroke patients

Autor: L. B. Nørregaard, K. A. Wickham, J. S. Jeppesen, N. Rytter, L. C. Christoffersen, L. Gliemann, M. Lawrence, P. A. Evans, C. Kruuse, Y. Hellsten
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Thrombosis Journal, Vol 22, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 1477-9560
DOI: 10.1186/s12959-024-00604-9
Popis: Abstract Introduction Older individuals and, in particular, individuals at risk of recurrent stroke, may be susceptible to thrombosis when participating in exercise, however, this aspect has not been well investigated. Methods Clot microstructure and conventional markers of thrombotic risk were determined in twenty lacunar stroke patients and fifteen healthy age-matched controls before, immediately after and 1 h after a bout of moderate intensity cycling exercise. Data were analyzed using a linear mixed model approach. Results At rest, clot microstructure (1.69 ± 0.07 vs. 1.64 ± 0.05, corresponding to a difference of ~ 50% in normalized clot mass; p = 0.009) and thrombocyte count (73%; p
Databáze: Directory of Open Access Journals
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