Trends and predictors of HIV-1 acquired drug resistance in Minas Gerais, Brazil: 2002–2012

Autor: Helena Duani, Agdemir Waleria Aleixo, Unaí Tupinambás
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Brazilian Journal of Infectious Diseases, Vol 21, Iss 2, Pp 148-154 (2017)
Druh dokumentu: article
ISSN: 1413-8670
DOI: 10.1016/j.bjid.2016.11.009
Popis: Several studies show that the prevalence of multidrug-resistant HIV-1 virus is declining over time. A retrospective cohort study was carried out to evaluate the trends of drug resistance in antiretroviral treatment-exposed individuals in a state of a middle-income country, Minas Gerais, southeast region of Brazil. We analyzed 2115 HIV-1 sequences from 2002 up to 2012, from 52 cities of Minas Gerais. The groups were analyzed according to the definitions: “IAS – 3 class mutations”, if ≥1 drug resistance mutation from IAS 2015 list (DRM) was present in each class; “No fully susceptible drugs” as the absence of any fully susceptible drug in Stanford algorithm; and “GSS ≥ 2″, when a maximum calculated GSS (genotypic susceptibility score) was ≥2 or ≥3, counting only drugs available in Brazil and USA at given calendar years. Time trends of resistance were analyzed by Cochran–Armitage test. We observed a decrease in the rate resistance mutations for PI, NRTI, “IAS – 3 class mutations”, and “No fully susceptible drugs” over these 11 years, from 69.2% to 20.7%, 92.3% to 90.2%, 46.2% to 22.5%, and 12.8% to 5.7%, respectively (p
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