| Autor: |
V. A. Bozhedomov, A. A. Kamalov, G. E. Bozhedomova, V. I. Kozlova, R. A. Kamarina, E. A. Epanchintseva |
| Jazyk: |
ruština |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Андрология и генитальная хирургия, Vol 20, Iss 1, Pp 108-119 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2070-9781 |
| DOI: |
10.17650/2070-9781-2019-20-1-108-119 |
| Popis: |
The study objective is to evaluate the effect of the Russia-made nutritional supplement AndroDoz® — a source of L-carnosine, coenzyme Q10, glycyrrhizate, selenium, zinc, vitamins A and E — on ejaculate characteristics in 12-week observational period in men with idiopathic infertility in the from of oligospermia in combination with astheno- and/or teratozoospermia.Materials and methods. Examination of men from infertile pairs was performed at out-patient subdivisions of specialized uroandrological clinics in accordance with the World Health Organization guidelines (2010). Patients satisfying inclusion criteria were randomized into 2 groups: the treatment group (n = 33) received AndroDoz® as 410 mg capsules 4 times a day; the control group (n = 23) didn»t receive treatment. Repeat examination was performed 12 weeks later. All patients received detailed instructions on healthy lifestyle.Results. In the treatment group, mean sperm concentration increased by 5.3 million/ml (p 0.05) and by 3 million/ml (p >0.05), respectively. In the treatment group, concentration increased in 58 % of cases (p >0.05), in the control group in 52 % (p >0.05). Mean percentage of fast progressive motile sperm (grade А) in the treatment group increased by 6.6 %, median by 9 % (p 0.05). Changes in percentage of sperm of other grades (В, С and D) and percentage of sperm with normal morphology in both groups were bidirectional and insignificant (p >0.05).Conclusions. In 73 % of patients with oligospermia receiving AndroDoz®, percentage of fast progressive motile sperm significantly increased. However, no significant differences were observed between the treatment and control groups which can be caused by insufficient power of the study. Continuation of the studies is required using larger patient samples and taking into account oxidative stress. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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