| Autor: |
Kohn Elise, Knezevic Vladimir, Lorang Dominique, Baibakov Galina, Vu Huan, He Mei, O'Connor Sarah, Patton Angela, Kayton Mark L, Miller Walter J, Alexander H Richard, Stirling David, Payvandi Faribourz, Muller George W, Libutti Steven K |
| Jazyk: |
angličtina |
| Rok vydání: |
2004 |
| Předmět: |
|
| Zdroj: |
Journal of Translational Medicine, Vol 2, Iss 1, p 4 (2004) |
| Druh dokumentu: |
article |
| ISSN: |
1479-5876 |
| DOI: |
10.1186/1479-5876-2-4 |
| Popis: |
Abstract Reliable quantitative evaluation of molecular pathways is critical for both drug discovery and treatment monitoring. We have modified the CAM assay to quantitatively measure vascular density, endothelial proliferation, and changes in protein expression in response to anti-angiogenic and pro-angiogenic agents. This improved CAM assay can correlate changes in vascular density with changes seen on a molecular level. We expect that these described modifications will result in a single in vivo assay system, which will improve the ability to investigate molecular mechanisms underlying the angiogenic response. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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