Sound conditioning protects hearing by activating the hypothalamic–pituitary–adrenal axis

Autor: Yeasmin Tahera, Inna Meltser, Peter Johansson, Hazim Salman, Barbara Canlon
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Zdroj: Neurobiology of Disease, Vol 25, Iss 1, Pp 189-197 (2007)
Druh dokumentu: article
ISSN: 1095-953X
85470759
DOI: 10.1016/j.nbd.2006.09.004
Popis: Sound conditioning primes the auditory system to low levels of acoustic stimuli and reduces damage caused by a subsequent acoustic trauma. This priming activates the HPA axis resulting in the elevation of plasma corticosterone with a consequent upregulation of glucocorticoid receptors (GR) in the cochlea and the paraventricular nucleus (PVN) of the hypothalamus in the mouse. This protective effect is blocked by adrenalectomy or pharmacological treatment with RU486+metyrapone. Sound conditioning prevents GR down-regulation induced by acoustic trauma and subsequently enhances GR activity in spiral ganglion neurons. Increased SRC-1 expression, triggered by sound conditioning, positively correlates with the upregulation of GR in the cochlea. These findings will help to define the cellular mechanisms responsible for protecting the auditory system from hearing loss by sound conditioning.
Databáze: Directory of Open Access Journals
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