Endothelin-1 stimulates human monocytes in vitro to release TNF-α , IL-1β and IL-6

Autor: E. Helset, T. Sildnes, R. Seljelid, Z.S. Konopski
Jazyk: angličtina
Rok vydání: 1993
Předmět:
Zdroj: Mediators of Inflammation, Vol 2, Iss 6, Pp 417-422 (1993)
Druh dokumentu: article
ISSN: 0962-9351
1466-1861
09629351
DOI: 10.1155/S0962935193000596
Popis: Increased plasma- and tissue levels of endothelin-1 (ET-1) during inflammatory diseases, have suggested a role of ET-1 in the pathophysiology of inflammatory reactions. The authors have studied the effect of ET-1 on cytokine release from monocytes and monocyte-derived macrophages. ET-1 increased secretion of TNF-α, IL-1β and IL-6 in a dose- and time-dependent manner. Optimal ET-1 concentration ranged from 0.01 to 1 nM. The maximal response was a 200 to 400% increase in cytokine release. A time-course study revealed that the pattern of cytokines induced by ET-1 was different in monocytes and macrophages, although an early increase in TNF-α was observed in both monocyte and macrophage supernatants. In conclusion, ET-1 stimulates monocytes and macrophages to release cytokines thereby demonstrating a potential role for ET-1 in regulation of inflammatory responses.
Databáze: Directory of Open Access Journals
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