Agomir-331 Suppresses Reactive Gliosis and Neuroinflammation after Traumatic Brain Injury

Autor:	Jin-Xing Wang, Xiao Xiao, Xuan-Cheng He, Bao-Dong He, Chang-Mei Liu, Zhao-Qian Teng
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	traumatic brain injury miR-331 IL-1β agomir glial scar neuroprotection Cytology QH573-671
Zdroj:	Cells, Vol 12, Iss 20, p 2429 (2023)
Druh dokumentu:	article
ISSN:	2073-4409
DOI:	10.3390/cells12202429
Popis:	Traumatic brain injury usually triggers glial scar formation, neuroinflammation, and neurodegeneration. However, the molecular mechanisms underlying these pathological features are largely unknown. Using a mouse model of hippocampal stab injury (HSI), we observed that miR-331, a brain-enriched microRNA, was significantly downregulated in the early stage (0–7 days) of HSI. Intranasal administration of agomir-331, an upgraded product of miR-331 mimics, suppressed reactive gliosis and neuronal apoptosis and improved cognitive function in HSI mice. Finally, we identified IL-1β as a direct downstream target of miR-331, and agomir-331 treatment significantly reduced IL-1β levels in the hippocampus after acute injury. Our findings highlight, for the first time, agomir-331 as a pivotal neuroprotective agent for early rehabilitation of HSI.
Databáze:	Directory of Open Access Journals
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