Investigation of potential serum biomarkers for the diagnosis of chronic back pain in horses
| Autor: | Abubakar Musa Mayaki, Intan-Shameha Abdul Razak, Noraniza Mohd Adzahan, Mazlina Mazlan, Rasedee Abdullah |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Macedonian Veterinary Review, Vol 46, Iss 1, Pp 79-87 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1409-7621 1857-7415 |
| DOI: | 10.2478/macvetrev-2023-0016 |
| Popis: | Back pain is one of the most common triggers of performance failure in athletic and riding horses. Diagnosis of equine back pain has been very challenging for equine practitioners, particularly in chronic cases. Therefore, the identification of blood biomarkers would facilitate the clinical differentiation of chronic back pain. This study aimed to investigate serum biomarkers of glial cell activation, axonal damage, and inflammation for the diagnosis of equine chronic back pain. Serum samples from forty horses comprising chronic back pain (CBP), back pain concurrent with lameness (BPL), lameness (LN), and healthy control (HC) (n=10 per group) were screened for ionized calcium-binding adaptor molecule 1 (Iba-1), glial fibrillary acidic protein (GFAP), phosphorylated neurofilament-H (pNF-H) by ELISA, and proinflammatory cytokines (IL-1β, IL-6, and TNF-α) by multiplex assay. Serum concentrations of GFAP (3.81±1.72 ng/mL) and pNF-H (0.76±0.18 ng/mL) were significantly (p |
| Databáze: | Directory of Open Access Journals |
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