Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation
| Autor: | Anne-Claire Jacomin, Ioannis P. Nezis |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Molecular & Cellular Oncology, Vol 7, Iss 1 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2372-3556 23723556 |
| DOI: | 10.1080/23723556.2019.1682309 |
| Popis: | Implication of autophagy in the downregulation of immune signaling pathways through the degradation of their components constitutes an emerging field of investigation. Our work showed that the selective interaction of Drosophila protein Kenny/IKKγ (CG16910) with the autophagic machinery is required for the degradation of the I-kappa B kinase complex. This regulatory mechanism is essential for the downregulation of the immune deficiency (IMD) pathway in response to commensal microbiota to prevent inflammation. |
| Databáze: | Directory of Open Access Journals |
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