Therapeutic potential of cannabis for surgical wound healing in rats
| Autor: | GD Akarsu, R Hobek Akarsu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Veterinární Medicína, Vol 69, Iss 8, Pp 297-306 (2024) |
| Druh dokumentu: | article |
| ISSN: | 0375-8427 1805-9392 48028398 |
| DOI: | 10.17221/21/2024-VETMED |
| Popis: | This study was conducted to evaluate the wound-healing activities of a Cannabis sativa L. plant extract and cannabidiol on incision wounds. An incision was created and sutured in rats under anaesthesia. Routine wound care procedures were applied for 10 days, followed by histological wound examinations. The cellular bioactivities of the hemp extract and CBD were assessed for MCP-1, EGF, BFGF, IL-8, and COL-1 using ELISA on the rat skin wound healing activity. A one-way ANOVA was used for the data analysis. The EGF values in the plasma were similar in the povidone-iodine, hemp seed oil, and hemp essential oil groups (P > 0.05). However, the EGF levels were lower in the CBD group compared to the other groups (P 0.05), whereas povidone iodine exhibited lower MCP-1 levels compared to the other groups (P 0.05). To our knowledge, this study is the first to evaluate the effects of CBD, seed oil, and hemp leaf extract on incision wound healing. It demonstrates that hemp extract holds greater potential benefits for wound healing compared to CBD. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|