| Autor: |
Fernando Freitas de Lima, Caroline Honaiser Lescano, Jucicléia da Silva Arrigo, Cláudia Andrea Lima Cardoso, Janclei Pereira Coutinho, Iluska Senna Bonfá Moslaves, Thalita Vieira do Nascimento Ximenes, Monica Cristina Toffoli Kadri, Simone Schneider Weber, Renata Trentin Perdomo, Cândida Aparecida Leite Kassuya, Maria do Carmo Vieira, Eliana Janet Sanjinez-Argandoña |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 13, Iss 4, p e0195678 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0195678 |
| Popis: |
The anti-inflammatory, antiproliferative and cytoprotective activity of the Attalea phalerata Mart. ex Spreng pulp oil was evaluated by in vitro and in vivo methods. As for the chemical profile, the antioxidant activity was performed by spectrophotometry, and the profile of carotenoids and amino acids by chromatography. Our data demonstrated that A. phalerata oil has high carotenoid content, antioxidant activity and the presence of 5 essential amino acids. In the in vitro models of inflammation, the oil demonstrated the capacity to inhibit COX1 and COX2 enzymes, the production of nitric oxide and also induces macrophages to spreading. In the in vivo models of inflammation, the oil inhibited edema and leukocyte migration in the Wistar rats. In the in vitro model of antiproliferative and cytoprotective activity, the oil was shown inactive against the kidney carcinoma and prostate carcinoma lineage cells and with cytoprotective capacity in murine fibroblast cells, inhibiting the cytotoxic action of doxorubicin. Therefore, it is concluded that A. phalerata pulp oil has anti-inflammatory effects with nutraceutical properties potential due to the rich composition. Moreover, the oil also has cytoprotective activity probably because of its ability to inhibit the action of free radicals. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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