| Autor: |
Prachi Umbarkar, PhD, Anand P. Singh, PhD, Manisha Gupte, PhD, Vipin K. Verma, PhD, Cristi L. Galindo, PhD, Yuanjun Guo, MD, Qinkun Zhang, MD, James W. McNamara, PhD, Thomas Force, MD, Hind Lal, PhD |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
JACC: Basic to Translational Science, Vol 4, Iss 1, Pp 41-53 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2452-302X |
| DOI: |
10.1016/j.jacbts.2018.10.003 |
| Popis: |
Summary: The role of the transforming growth factor (TGF)-β pathway in myocardial fibrosis is well recognized. However, the precise role of this signaling axis in cardiomyocyte (CM) biology is not defined. In TGF-β signaling, SMAD4 acts as the central intracellular mediator. To investigate the role of TGF-β signaling in CM biology, the authors deleted SMAD4 in adult mouse CMs. We demonstrate that CM-SMAD4–dependent TGF-β signaling is critical for maintaining cardiac function, sarcomere kinetics, ion-channel gene expression, and cardiomyocyte survival. Thus, our findings raise a significant concern regarding the therapeutic approaches that rely on systemic inhibition of the TGF-β pathway for the management of myocardial fibrosis. Key Words: cardiomyocyte, cardiomyopathy, fibrosis, heart failure, SMAD4, TGF-β |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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