Transient hyperammonemia associated with postictal state in generalized convulsion

Autor: Kuan-Ting Liu, Shih-Chia Yang, I.-Jeng Yeh, Tzeng-Jih Lin, Chi-Wei Lee
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Kaohsiung Journal of Medical Sciences, Vol 27, Iss 10, Pp 453-456 (2011)
Druh dokumentu: article
ISSN: 1607-551X
DOI: 10.1016/j.kjms.2011.06.005
Popis: Previous studies revealed that transient hyperammonemia was noted after generalized convulsion. This study was undertaken to analyze the association between postictal state and serum ammonia levels. Adult patients presenting to the emergency department with seizures were included. Serum ammonia and other blood tests were compared between patients with full recovery of consciousness after generalized convulsion and those who had not completely regained consciousness. Patients who had not completely regained consciousness (7 of 7, 100%) had higher rate (p=0.035) of hyperammonemia compared with patients who had fully regained consciousness (4 of 10, 40%) and higher level of serum ammonia (246±96 μg/dL vs. 102±99 μg/dL, p=0.006). All patients who showed postictal consciousness level impairment on arrival at the emergency department had elevated serum ammonia at that time. Transient hyperammonemia is associated with postictal confusion.
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