The Effects of Thymoquinone of Black Seed Plant on Sperm Parameters, Hormones, and Oxidative Stress in Mice Poisoned by Chlorpyrifos

Autor: Azita Nozad, Parichehr Hanachi, Shahrdad Mohebali
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Archives of Advances in Biosciences, Vol 15, Iss 1, Pp 1-8 (2024)
Druh dokumentu: article
ISSN: 2783-1264
DOI: 10.22037/aab.v15i1.44232
Popis: Introduction: The Nigella sativa plant, commonly known as black seed, contains a significant compound known as thymoquinone, which exhibits remarkable therapeutic properties. This study aimed to assess the potential therapeutic effects of thymoquinone on the adverse effects of chlorpyrifos toxicity, considering the importance of reproductive capacity and the detrimental impacts of agricultural toxins. Materials and Methods: Various parameters were assessed in 36 NRMI male mice including testosterone and luteinizing hormone (LH) hormone secretion, sperm count and motility, as well as an antioxidant activity measured by TAC (Total Antioxidant Capacity), MDA (malondialdehyde), and SOD (Superoxide Dismutase). Both thymoquinone and chlorpyrifos were injected intraperitoneally for 14 days. Results: In tests related to sperms, chlorpyrifos caused a severe decrease in sperm motility and number (p
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