Possible Role of GABAergic Depolarization in Neocortical Neurons in Generating Hyperexcitatory Behaviors during Emergence from Sevoflurane Anesthesia in the Rat
| Autor: | Byung-Gun Lim, Feng-Yan Shen, Young-Beom Kim, Woong Bin Kim, Yoon Sik Kim, Hee Chul Han, Mi-Kyoung Lee, Myoung-Hoon Kong, Yang In Kim |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | ASN Neuro, Vol 6 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1759-0914 1759-9091 |
| DOI: | 10.1042/AN20140004 |
| Popis: | Hyperexcitatory behaviors occurring after sevoflurane anesthesia are of serious clinical concern, but the underlying mechanism is unknown. These behaviors may result from the potentiation by sevoflurane of GABAergic depolarization/excitation in neocortical neurons, cells implicated in the genesis of consciousness and arousal. The current study sought to provide evidence for this hypothesis with rats, the neocortical neurons of which are known to respond to GABA (γ-aminobutyric acid) with depolarization/excitation at early stages of development (i.e., until the second postnatal week) and with hyperpolarization/inhibition during adulthood. Employing behavioral tests and electrophysiological recordings in neocortical slice preparations, we found: (1) sevoflurane produced PAHBs (post-anesthetic hyperexcitatory behaviors) in postnatal day (P)1–15 rats, whereas it failed to elicit PAHBs in P16 or older rats; (2) GABAergic PSPs (postsynaptic potentials) were depolarizing/excitatory in the neocortical neurons of P5 and P10 rats, whereas mostly hyperpolarizing/inhibitory in the cells of adult rats; (3) at P14–15, |
| Databáze: | Directory of Open Access Journals |
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