| Autor: |
Nobuhiko Nakamura, Nobuhiro Kanemura, Takuro Matsumoto, Hiroshi Nakamura, Yuhei Shibata, Kimihiro Yamaguchi, Junichi Kitagawa, Yoshikazu Ikoma, Tomomi Suzaki, Yuto Kaneda, Soranobu Ninomiya, Eri Takada, Takeshi Hara, Hisashi Tsurumi, Masahito Shimizu |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Nutrients, Vol 16, Iss 16, p 2653 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2072-6643 |
| DOI: |
10.3390/nu16162653 |
| Popis: |
This study investigated the prognostic impact of vitamin D deficiency and reduced skeletal muscle mass in diffuse large B-cell lymphoma (DLBCL) patients. A retrospective analysis of 186 newly diagnosed DLBCL patients from 2012 to 2022 was conducted, measuring serum 25-hydroxyvitamin D [25(OH)D] levels and the skeletal muscle index (SMI). Decreased vitamin D levels were linked to more severe DLBCL disease, with a median 25(OH)D concentration of 13 (4.0–27) ng/mL. Males in the group with a low SMI had a considerably lower 25(OH)D concentration. The optimal threshold of 25(OH)D levels for overall survival (OS) was 9.6 ng/mL, with lower values associated with a higher likelihood of recurrence and mortality. Multivariable analysis showed hazard ratios for OS of 1.4 [95% CI 0.77–2.5] for a low SMI and 3.2 [95% CI 1.8–5.8] for low 25(OH)D concentration. The combination of a low SMI and low vitamin D concentration resulted in the worst prognosis. Thus, low levels of vitamin D associated with disease progression significantly impact DLBCL prognosis, which can be further stratified by the SMI, providing valuable insights for patient management and potential therapeutic interventions. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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