Leukocyte cell population data as potential markers of COVID-19 disease characterization
| Autor: | Introcaso Giovanni, Galotta Arianna, Salvini Laura, Faioni Elena Maria, Bonomi Alice, Assanelli Emilio, Biondi Maria Luisa |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Medical Biochemistry, Vol 42, Iss 3, Pp 454-459 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1452-8258 1452-8266 |
| DOI: | 10.5937/jomb0-41589 |
| Popis: | Background: The usefulness of leukocyte cell population data (CPD) is currently being investigated. In COVID-19 pandemic several reports showed the clinical importance of hematological parameters. Our study aimed to assess CPDs in Sars CoV-2 patients as new disease markers. Methods: From February to April 2020 (1st wave) 540 and from September to December 2020 (2nd wave) 2821 patients respectively were enrolled. SARS CoV-2 infection diagnosis was carried out by Multiplex rRT-PCR from nasopharyngeal swabs. CPDs were detected by XN 2000 hematology analyzer (Sysmex Corporation). A comparison between two disease waves was performed. Additionally, C-reactive protein (CRP) and lactate dehydrogenase (LDH) were assayed. Results: CPDs were classified into: cell complextity, DNA/RNA content and abnormal sized cells. We detected parameters increased from the reference population for all cell types for both 1st and 2nd wave (p |
| Databáze: | Directory of Open Access Journals |
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